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An exciting opportunity is available for an Analytical Development Scientist to join a growing start-up. With state-of-the-art facilities and a robust pipeline of upcoming projects, this role offers the chance to contribute to innovative research and development.

Responsibilities:

The purpose of this role is to develop analytical methodologies part of an innovative multidisciplinary team that will develop the next generation of mammalian expression systems & cells lines to enable highly productive pharmaceutical bioprocesses and, ultimately, more cost effective Immunotherapeutics.

Design, plan, and develop analytical assays utilising a variety of different techniques and throughputs ensuring that deliverables are successfully met within timelines

Execute analytical assays with a high level of skill and in a reliable and reproducible way

Author SOPs, training documents & COSHH forms as key deliverables

Train team members to a high degree of competence to ensure data integrity

Document research findings clearly in a lab book

Communicate regularly in group meetings and prepare and deliver presentations to project team and internal stakeholders

Along with team members, provide routine laboratory maintenance, including participating in equipment upkeep, cleaning rotas and laboratory consumables stock management

Shared responsibility for out-of-hours cell culture maintenance.

Ensure that laboratory health, safety and quality procedures are followed

Support the preparation of laboratory risk assessments and maintenance of health and safety protocols

Maintain the confidentiality of the project and protocols

Keep abreast of current technologies and relevant scientific literature to help identify opportunity for improvements and reduction of costs
Minimum Required Qualifications

MSc/PhD in Biochemistry, Molecular Biology or related field

MSc with 5+ years of industry experience or PhD with 2 years industry experience
Essential Experience:

Extensive experience of developing and executing a range of analytical methodologies including HPLC/UPLC & LC-MS to characterise antibody titre and CQAs

Experience of developing high-throughput analyses within automated target discovery pipelines

Evidence of executing a range of molecular and cell biology assays to a high standard including FACS, qRT-PCR, Western Blotting & ELISA

Skilled in experimental design and troubleshooting

Application of Design of Experiments (DOE) to rationalise experiment design

Experience of writing SOPs, training documents and risk assessment

Experience of training other team members to a high level of competency

Experience of working with bioprocess relevant cell lines eg. CHO or HEK293

Familiarity of mammalian cell line development including generation of GM/GE cell lines, single cell cloning and CRISPR / ORF library screens

Skilled in molecular biology techniques including PCR, qRT-PCR, Western Blot, ELISA, plasmid preparation, plasmid cloning, site directed mutagenesis & FACS

Ability to work independently and as part of team

Experience of planning experiments with a given timeframe

Good numeracy, computer and communication skills
Desirable Experience:

Experience with automation and high-throughput technologies applied to mammalian cell line generation eg. Beacon, 96 deep well plate model systems & Ambr15

Familiarity of working with large datasets including transcriptomic / proteomic datasets

Experience of mammalian cell culture and related techniques including passaging, banking, transfection, nucleofection & genotyping

Experience of working safely with 3rd generation lentiviral plasmid systems within a CAT2.0 environment
Skills and personality:

Innovative mindset

Advanced problem-solving skill

Enthusiasm and initiative

Driven to deliver

Reliable and responsible

Able to multitask

Good time management and organisation skills

Excellent communication skills both written and spoken

Happy in a growing and multi-disciplinary team